BDBM50466664 CHEMBL4292341

SMILES OCc1cccc(c1)-c1c[nH]c2ncnc(-c3ccc4CC[C@H](NC#N)c4c3)c12

InChI Key InChIKey=INXMROPBPUKGSQ-UHFFFAOYSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50466664   

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466664(CHEMBL4292341)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant human GST-tagged JAK3 JH1 domain using KAIETDKEYYTVKD-NH2 as substrate in presence of ATP at Km concentration by coupled PK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466664(CHEMBL4292341)
Affinity DataIC50: 78nMAssay Description:Inhibition of recombinant human GST-tagged JAK3 JH1 domain using KAIETDKEYYTVKD-NH2 as substrate in presence of 1 mM ATP concentration by coupled PK/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466664(CHEMBL4292341)
Affinity DataIC50: 498nMAssay Description:Inhibition of JAK3 in human PBMC assessed as reduction in IL15-induced STAT5 phosphorylation preincubated for 75 mins followed by IL15 addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466664(CHEMBL4292341)
Affinity DataIC50: 733nMAssay Description:Inhibition of recombinant human GST-tagged JAK1 using KAIETDKEYYTVKD-NH2 as substrate in presence of ATP at Km concentration by coupled PK/LDH assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466664(CHEMBL4292341)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of BMX (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466664(CHEMBL4292341)
Affinity DataIC50: 2.99E+3nMAssay Description:Inhibition of TXK (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466664(CHEMBL4292341)
Affinity DataIC50: 3.54E+3nMAssay Description:Inhibition of HER4 (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50466664(CHEMBL4292341)
Affinity DataIC50: 7.84E+3nMAssay Description:Inhibition of JAK1/TYK2 in human PBMC assessed as reduction in IL10-induced STAT3 phosphorylation preincubated for 75 mins followed by IL10 addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466664(CHEMBL4292341)
Affinity DataIC50: 8.96E+3nMAssay Description:Inhibition of TEC (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466664(CHEMBL4292341)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of recombinant human GST-tagged JAK1 using KAIETDKEYYTVKD-NH2 as substrate in presence of 1 mM ATP concentration by coupled PK/LDH assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466664(CHEMBL4292341)
Affinity DataIC50: 9.93E+3nMAssay Description:Inhibition of recombinant human GST-tagged JAK2 using KAIETDKEYYTVKD-NH2 as substrate in presence of 1 mM ATP concentration by coupled PK/LDH assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466664(CHEMBL4292341)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BTK (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466664(CHEMBL4292341)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50466664(CHEMBL4292341)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human His-tagged TYK2 expressed in SF21/baculovirus expression system using KAIETDKEYYTVKD-NH2 as substrate in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466664(CHEMBL4292341)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK3 in human whole blood assessed as reduction in IL15-induced STAT5 phosphorylation preincubated for 75 mins followed by IL15 additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466664(CHEMBL4292341)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ITK (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466664(CHEMBL4292341)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BLK (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50466664(CHEMBL4292341)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HER2 (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50466664(CHEMBL4292341)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAP2K7 (unknown origin) in presence of 1 mM ATP concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed