BDBM50468020 CHEMBL4287852

SMILES C[C@@H]1COCCN1c1cc(nc(n1)-n1c(N)nc2cc(Cl)ccc12)C1(CC1)S(C)(=O)=O

InChI Key InChIKey=XTNQQHNHHHQJOC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50468020   

TargetSerine/threonine-protein kinase ATR(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50468020(CHEMBL4287852)
Affinity DataIC50: 21nMAssay Description:Inhibition of ATR in human HeLa cell nuclear extract using GST-fused p53N66 as substrate preincubated for 10 mins followed by ATP addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50468020(CHEMBL4287852)
Affinity DataIC50: 870nMAssay Description:Inhibition of ATR in human HT29 cells after 60 mins by Hoechst 33258 staining-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed