BDBM50468658 CHEMBL4278385

SMILES CCOC(=O)c1c(Cc2c(C)cc(C)cc2C)[nH]c2c1cc(O)c1ccccc21

InChI Key InChIKey=AIJWLLLWCZXWOI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50468658   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania Luigi Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50468658(CHEMBL4278385)
Affinity DataIC50: 130nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
University of Campania Luigi Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50468658(CHEMBL4278385)
Affinity DataIC50: 5.88E+4nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from IL-1beta-stimulated human A549 cells preincubated for 15 mins followed by PGH2 addition m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Campania Luigi Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50468658(CHEMBL4278385)
Affinity DataIC50: 298nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed