BDBM50468698 CHEMBL4277548

SMILES [O-][N+](=O)c1ccc2oc(cc(=O)c2c1)C(=O)NCCC1CCN(Cc2ccccc2)CC1

InChI Key InChIKey=ONXNRNIGCHXJJM-UHFFFAOYSA-N

Data  3 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50468698   

TargetSigma non-opioid intracellular receptor 1(Guinea pig)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM50468698(CHEMBL4277548)
Affinity DataKi:  0.980nMAssay Description:Displacement of (+)-[3H]pentazocine from guinea pig brain membrane sigma1 receptor by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM50468698(CHEMBL4277548)
Affinity DataKi:  12nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using varying levels of acetylthiocholine iodide as substrate by Lineweaver-burk plot ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM50468698(CHEMBL4277548)
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate pretreated for 5 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM50468698(CHEMBL4277548)
Affinity DataKi:  287nMAssay Description:Displacement of [3H]DTG from sigma2 receptor in rat liver membranes by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCholinesterase(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM50468698(CHEMBL4277548)
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of human serum BuChE using butyrylthiocholine as substrate pretreated for 5 mins followed by substrate addition and measured for 5 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM50468698(CHEMBL4277548)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of human 5-lipoxygenase using arachidonic acid as substrate pretreated for 10 mins followed by substrate and ATP addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM50468698(CHEMBL4277548)
Affinity DataIC50: 2.05E+4nMAssay Description:Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using p-tyramine as substrate pretreated for 15 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
IQM-CSIC

Curated by ChEMBL
LigandPNGBDBM50468698(CHEMBL4277548)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using p-tyramine as substrate pretreated for 15 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed