BDBM50469246 CHEMBL4289707

SMILES [H][C@@]12C[C@@]3([H])C[C@@](CNc4nc(NCc5ccccc5OC(F)(F)F)ncc4C#N)(C1)C[C@@]([H])(C2)[C@H]3NCCO

InChI Key

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50469246   

TargetProtein kinase C theta type(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50469246(CHEMBL4289707)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of recombinant full-length human PKCtheta using STK1-biotin as substrate preincubated for 60 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50469246(CHEMBL4289707)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of PKCtheta in human Jurkat cells transfected with pGL3-IL2 pro 43 plasmid assessed as suppression of IL-2 production after 14 hrs by fire...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetProtein kinase C epsilon type(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50469246(CHEMBL4289707)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant N-terminal GST-fused full-length human PKCepsilon expressed in Baculovirus expression system using STK1-biotin as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50469246(CHEMBL4289707)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant N-terminal GST-fused full-length human PKCdelta expressed in Baculovirus expression system using STK1-biotin as substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50469246(CHEMBL4289707)
Affinity DataIC50: 84nMAssay Description:Inhibition of recombinant N-terminal GST-fused full-length human PKCalpha expressed in Baculovirus expression system using STK1-biotin as substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetProtein kinase C eta type(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50469246(CHEMBL4289707)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant N-terminal GST-fused full-length human PKCeta expressed in Baculovirus expression system using STK1-biotin as substrate aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50469246(CHEMBL4289707)
Affinity DataIC50: 410nMAssay Description:Inhibition of recombinant N-terminal GST-fused full-length human PKCbeta1 expressed in Baculovirus expression system using STK1-biotin as substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50469246(CHEMBL4289707)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant N-terminal GST-fused full-length human PKCzeta expressed in Baculovirus expression system using STK1-biotin as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50469246(CHEMBL4289707)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant N-terminal GST-fused full-length human PKCgamma expressed in Baculovirus expression system using STK1-biotin as substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed