BDBM50469457 CHEMBL4286698
SMILES Nc1cc(C(F)F)c(cn1)-c1nc(nc(n1)N1C2CCC1COC2)N1C2CCC1COC2
InChI Key InChIKey=UGDKPWVVBKHRDK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 20 hits for monomerid = 50469457
Affinity DataIC50: 85nMAssay Description:Inhibition of mTORC1 in human A2058 cells assessed as reduction in ribosomal protein S6 phosphorylation at Ser235/236 residues incubated for 1 hr by ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
University of Basel
Curated by ChEMBL
University of Basel
Curated by ChEMBL
Affinity DataKd: 2.75E+3nMAssay Description:Binding affinity to human wild-type partial length VPS34 (S282 to H879 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
Affinity DataKd: >3.00E+4nMAssay Description:Binding affinity to wild-type human full-length PI4Kbeta (M1 to M828 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.270nMAssay Description:Binding affinity to wild-type human partial length mTOR (L1382 to W2549 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of mTORC2 in human A2058 cells assessed as reduction in PKB phosphorylation at S473 residues incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
University of Basel
Curated by ChEMBL
University of Basel
Curated by ChEMBL
Affinity DataKd: 1.80E+4nMAssay Description:Binding affinity to human wild-type partial length PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of Basel
Curated by ChEMBL
University of Basel
Curated by ChEMBL
Affinity DataKd: 1.00E+3nMAssay Description:Binding affinity to human wild-type partial length PI3Kalpha (R108 to N1068 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
University of Basel
Curated by ChEMBL
University of Basel
Curated by ChEMBL
Affinity DataKd: 2.30E+4nMAssay Description:Binding affinity to human wild-type partial length PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.270nMAssay Description:Inhibition of human mTOR (1382 to 2549 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
University of Basel
Curated by ChEMBL
University of Basel
Curated by ChEMBL
Affinity DataKd: 2.20E+4nMAssay Description:Binding affinity to human wild-type partial length PI3Kbeta (P118 to S1070 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
University of Basel
Curated by ChEMBL
University of Basel
Curated by ChEMBL
Affinity DataKd: 2.75E+3nMAssay Description:Inhibition of human VPS34 (282 to 879 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of Basel
Curated by ChEMBL
University of Basel
Curated by ChEMBL
Affinity DataKd: 1.00E+3nMAssay Description:Inhibition of human PI3Kalpha (108 to 1068 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
Affinity DataKd: >3.00E+4nMAssay Description:Inhibition of human PI4Kbeta (1 to 828 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
University of Basel
Curated by ChEMBL
University of Basel
Curated by ChEMBL
Affinity DataKd: 1.80E+4nMAssay Description:Inhibition of human PI3Kgamma (144 to 1102 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
University of Basel
Curated by ChEMBL
University of Basel
Curated by ChEMBL
Affinity DataKd: 2.30E+4nMAssay Description:Inhibition of human PI3Kdelta (108 to 1044 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
University of Basel
Curated by ChEMBL
University of Basel
Curated by ChEMBL
Affinity DataKd: 2.20E+4nMAssay Description:Inhibition of human PI3Kbeta (118 to 1070 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Binding affinity to recombinant human GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus after 1 hr by TR-FRET displac...More data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-fused mTOR (1360 to 2549 residues) expressed in b...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of Basel
Curated by ChEMBL
University of Basel
Curated by ChEMBL
Affinity DataKi: 4.20E+3nMAssay Description:Binding affinity to recombinant N-terminal His6-tagged P110alpha catalytic domain (unknown origin) after 1 hr by TR-FRET displacement assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of Basel
Curated by ChEMBL
University of Basel
Curated by ChEMBL
Affinity DataKi: 4.20E+3nMAssay Description:Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human full-length N-terminal His6-tagged p110alpha/p85alpha expressed ...More data for this Ligand-Target Pair