BDBM50469473 CHEMBL4280087

SMILES Nc1cc(C(F)F)c(cn1)-c1nc(nc(n1)N1CCOCC1)N1CCOCC1

InChI Key InChIKey=UFLPGOLPDASTON-UHFFFAOYSA-N

Data  2 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50469473   

TargetSerine/threonine-protein kinase mTOR(Human)
University of Basel

Curated by ChEMBL

LigandBDBM50469473(CHEMBL4280087)Copy SMILESCopy InChI

Affinity DataKi:  6.90nMAssay Description:Binding affinity to recombinant human GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus after 1 hr by TR-FRET displac...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/19/2020
Entry Details Article
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of Basel

Curated by ChEMBL

LigandBDBM50469473(CHEMBL4280087)Copy SMILESCopy InChI

Affinity DataKi:  12nMAssay Description:Binding affinity to recombinant N-terminal His6-tagged P110alpha catalytic domain (unknown origin) after 1 hr by TR-FRET displacement assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/19/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL