BDBM50473078 CHEMBL341662

SMILES O=C(N[C@@H]1N=C(c2ccccc2)c2cc(cc3CCN(c23)C1=O)N1CCCC1)c1ccncc1

InChI Key InChIKey=QSYHFFMXNLYLGJ-UHFFFAOYSA-N

Data  3 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50473078   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50473078(CHEMBL341662)Copy SMILESCopy InChI

Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of phosphodiesterase type 4 isozyme (PDE4) from the U937 human cell line.More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/22/2020
Entry Details Article
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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50473078(CHEMBL341662)Copy SMILESCopy InChI

Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of phosphodiesterase 3 (PDE3) isolated from the dog aortaMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/22/2020
Entry Details Article
Copy BDB DOIPubMed
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TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50473078(CHEMBL341662)Copy SMILESCopy InChI

Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea.More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/22/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL