BDBM50474811 CHEMBL316065

SMILES COC[C@H](C)Nc1nccc(n1)-c1c(-c2ccc(F)cc2)c(=O)n2CCCn12

InChI Key InChIKey=NKIIJQFBQXIXNY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50474811   

TargetMitogen-activated protein kinase 11/12/13/14(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50474811(CHEMBL316065)
Affinity DataIC50: 27nMAssay Description:Inhibition of human Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50474811(CHEMBL316065)
Affinity DataIC50: 39nMAssay Description:Inhibition of LPS-stimulated p38-related IL1-beta production in human peripheral blood mononuclear cells (PBMC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50474811(CHEMBL316065)
Affinity DataIC50: 50nMAssay Description:Inhibitory activity against LPS-stimulated TNF-alpha production in human monocytic cells (THP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50474811(CHEMBL316065)
Affinity DataIC50: 16nMAssay Description:Inhibition of LPS-stimulated p38-related TNF-alpha production in human peripheral blood mononuclear cells (PBMC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed