BDBM50477394 CHEMBL238732

SMILES Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5OCC(=O)Nc5c4)CC3)cc(Cl)cc2n1

InChI Key InChIKey=VNCBCPIVWAMDIB-UHFFFAOYSA-N

Data  12 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50477394   

Target5-hydroxytryptamine receptor 1A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50477394(CHEMBL238732)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]WAY-100635 from human cloned 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50477394(CHEMBL238732)
Affinity DataKi:  63nMAssay Description:Inhibition of [3H]5-HT uptake at SERT in rat cortical synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50477394(CHEMBL238732)
Affinity DataKi:  79nMAssay Description:Displacement of [3H]5CT from human cloned 5HT7a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50477394(CHEMBL238732)
Affinity DataKi:  631nMAssay Description:Displacement of [3H]5-HT from human cloned 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50477394(CHEMBL238732)
Affinity DataKi:  631nMAssay Description:Displacement of [3H]5-HT from human cloned 5HT1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50477394(CHEMBL238732)
Affinity DataKi:  1.26E+3nMAssay Description:Displacement of [125I]iodosulpiride from human cloned D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50477394(CHEMBL238732)
Affinity DataKi:  1.59E+3nMAssay Description:Binding affinity at adrenergic beta 1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50477394(CHEMBL238732)
Affinity DataKi:  2.51E+3nMAssay Description:Displacement of [3H]mesulergine from human cloned 5HT2C receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50477394(CHEMBL238732)
Affinity DataKi:  2.51E+3nMAssay Description:Displacement of [125I]iodosulpiride from human cloned D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50477394(CHEMBL238732)
Affinity DataKi:  3.16E+3nMAssay Description:Displacement of [3H]ketanserin from human cloned 5HT2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50477394(CHEMBL238732)
Affinity DataKi:  3.16E+3nMAssay Description:Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50477394(CHEMBL238732)
Affinity DataKi: <1.00E+4nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed