BDBM50481780 CHEMBL599539

SMILES [O-]C(=O)C[C@@H]1CCN([C@H](CCc2ccccc2)c2ccc(nc2)C(F)(F)F)[C@@H](C1)c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=PVCUYYSXSXNIAS-UHFFFAOYSA-M

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50481780   

TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481780(CHEMBL599539)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481780(CHEMBL599539)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta42 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed