BDBM50481789 CHEMBL604727

SMILES OC(=O)Cc1ccc(-c2ccc(cc2)C(F)(F)F)c(c1)-c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=HZJFCYVIHLOWHV-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50481789   

TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481789(CHEMBL604727)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as decrease in Abeta42 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481789(CHEMBL604727)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481789(CHEMBL604727)
Affinity DataEC50:  7.94E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as increase in Abeta38 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481789(CHEMBL604727)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta42 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481789(CHEMBL604727)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as effect on Abeta40 level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481789(CHEMBL604727)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as decrease in total Abeta level after 24 hrs by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed