BDBM50481797 CHEMBL599146

SMILES O=C([O-])C[C@@H]4CCN([C@@H](c1ccc(C(F)(F)F)nc1)C2CCCCC2)[C@H](c3ccc(C(F)(F)F)cc3)C4

InChI Key InChIKey=UKATWJPGHPBHAB-UHFFFAOYSA-M

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50481797   

TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481797(CHEMBL599146)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50481797(CHEMBL599146)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta42 formation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed