BDBM50481895 CHEMBL1075708

SMILES OC(=O)COc1ccc2c(c1)n(Cc1ccc(cc1)-c1ccccc1C#N)c1ccccc21

InChI Key InChIKey=RPUBEQJPWNAZHS-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50481895   

TargetPresenilin-1(Human)
Technische Universit£T Darmstadt

Curated by ChEMBL
LigandPNGBDBM50481895(CHEMBL1075708)
Affinity DataIC50: 8.00E+4nMAssay Description:Modulation of gamma-secretase in human H4 cells assessed as inhibition of in amyloid beta40 production by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Technische Universit£T Darmstadt

Curated by ChEMBL
LigandPNGBDBM50481895(CHEMBL1075708)
Affinity DataEC50: >8.00E+4nMAssay Description:Modulation of gamma-secretase in human H4 cells assessed as increase in amyloid beta38 production by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Technische Universit£T Darmstadt

Curated by ChEMBL
LigandPNGBDBM50481895(CHEMBL1075708)
Affinity DataIC50: 8.00E+4nMAssay Description:Modulation of gamma-secretase in human H4 cells assessed as inhibition of in amyloid beta42 production by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed