BDBM50482031 CHEMBL1089000

SMILES CC[C@H]1N([C@H](Cc2n[nH]cc12)c1ccc(Cl)cc1)S(=O)(=O)c1ccc(Cl)cc1

InChI Key InChIKey=PUBWZOHDDYWHMC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50482031   

TargetPresenilin-1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50482031(CHEMBL1089000)
Affinity DataIC50: 22nMAssay Description:Inhibition of gamma-secretase-mediated APP cleavage in human IMR-32 cells assessed as amyloid beta40 level after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50482031(CHEMBL1089000)
Affinity DataIC50: 1.55E+4nMAssay Description:Inhibition of gamma-secretase-mediated notch cleavage in human SNC cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50482031(CHEMBL1089000)
Affinity DataIC50: 126nMAssay Description:Inhibition of gamma-secretase-mediated notch cleavage in human IMR-32 cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed