BDBM50482548 CHEMBL1215537

SMILES CCC(C)\C=C\C=C\C=C\C(=O)\C=C(/O)C1=C2C=C(CC(O)CO)\C(=C\NCc3ccccc3)C(=O)[C@]2(C)OC1=O

InChI Key InChIKey=SEDLZMVHCSVJSA-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50482548   

TargetHeat shock protein HSP 90-alpha/90-beta(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50482548(CHEMBL1215537)
Affinity DataEC50:  2.32E+3nMAssay Description:Inhibition of HSP90 in human A431 cells assessed as down-regulation of survivin protein after 24 hrs by immunoblottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50482548(CHEMBL1215537)
Affinity DataEC50:  3.57E+3nMAssay Description:Inhibition of HSP90 in human A431 cells assessed as down-regulation of EGFR protein after 24 hrs by immunoblottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50482548(CHEMBL1215537)
Affinity DataEC50:  4.93E+3nMAssay Description:Inhibition of HSP90 in human A431 cells assessed as down-regulation of Cdk4 protein after 24 hrs by immunoblottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50482548(CHEMBL1215537)
Affinity DataEC50:  8.93E+3nMAssay Description:Inhibition of HSP90 in human A431 cells assessed as down-regulation of Akt protein after 24 hrs by immunoblottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed