BDBM50482595 CHEMBL1221487

SMILES CC\C(=C/c1ccc(OC)c(c1)C(=O)NCc1ccc(cc1)C(F)(F)F)C(O)=O

InChI Key InChIKey=BRSFJRDXVFLOMX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50482595   

TargetPresenilin-1(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50482595(CHEMBL1221487)
Affinity DataIC50: 3.27E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 40 production by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50482595(CHEMBL1221487)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing NotchdeltaE assessed as inhibition of notch cleavage by luciferase reporter gene assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Okayama University Graduate School of Medicine

Curated by ChEMBL
LigandPNGBDBM50482595(CHEMBL1221487)
Affinity DataIC50: 2.24E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 42 production by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed