BDBM50484728 CHEMBL1950892

SMILES CNC(=O)c1cc(Oc2ccc3nc(Nc4ccc(cc4)C(F)(F)F)ncc3c2)ccn1

InChI Key InChIKey=TVMDXCWYKITPSK-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50484728   

TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50484728(CHEMBL1950892)
Affinity DataIC50: 67nMAssay Description:Inhibition of N-terminus His6-tagged Braf V600E mutant expressed in insect Sf9 cells assessed as Mek phosphorylation after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50484728(CHEMBL1950892)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of Braf V600E mutant-mediated Erk phosphorylation in human SK-MEL-28 cells after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed