BDBM50485687 CHEMBL2153512

SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(C4CC4)c3c2)c1F

InChI Key InChIKey=MPCHYONBCBSBOD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50485687   

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50485687(CHEMBL2153512)
Affinity DataIC50: 3nMAssay Description:Inhibition of full length B-Raf V600E mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50485687(CHEMBL2153512)
Affinity DataIC50: 520nMAssay Description:Inhibition of B-Raf V600E mutant in human Malme-3M cells assessed as ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed