BDBM50494300 CHEMBL3086305

SMILES [H][C@]12Cc3ccc(O)cc3[C@@]3(CCN1CC1CC1)Cc1nc(NC(C)=O)sc1C[C@@]23[H]

InChI Key

Data  3 KI  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50494300   

TargetMu-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50494300(CHEMBL3086305)
Affinity DataKi:  0.0850nMAssay Description:Displacement of [3H]-DAMGO from human mu opioid receptor transfected in CHO cells after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50494300(CHEMBL3086305)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]-U69593 from human kappa opioid receptor transfected in CHO cells after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50494300(CHEMBL3086305)
Affinity DataEC50:  0.520nMAssay Description:Agonist activity at human mu opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50494300(CHEMBL3086305)
Affinity DataKi:  0.650nMAssay Description:Displacement of [3H]-naltrindole from human delta opioid receptor transfected in CHO cells after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50494300(CHEMBL3086305)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at human mu opioid receptor transfected in CHO cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS binding after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50494300(CHEMBL3086305)
Affinity DataEC50:  3.30nMAssay Description:Agonist activity at human kappa opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50494300(CHEMBL3086305)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human mu opioid receptor transfected in CHO cells assessed as inhibition of U50488-induced [35S]GTPgammaS binding after 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed