BDBM50494493 CHEMBL3092181

SMILES CNS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(C#N)c(OC(=O)N(C)C)cc3oc2=O)c1

InChI Key InChIKey=PENNERFNXWMJDP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50494493   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50494493(CHEMBL3092181)
Affinity DataIC50: 55nMAssay Description:Inhibition of C-Raf (unknown origin) assessed as phosphorylation of MEK1 after 45 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50494493(CHEMBL3092181)
Affinity DataIC50: 85nMAssay Description:Inhibition of MEK1 (unknown origin) assessed as phosphorylation of Erk2 preincubated for 30 mins followed by FAM-Erktide addition measured after 60 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed