BDBM50495901 CHEMBL3115253

SMILES Cn1cncc1[C@@](C)(O)C1=Cc2cccnc2[C@@H](N2CCN(CC2)C(=O)OC(C)(C)C)c2ccc(Cl)cc12

InChI Key InChIKey=BAHABGBETCGAQD-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50495901   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL

LigandBDBM50495901(CHEMBL3115253)Copy SMILESCopy InChI

Affinity DataIC50: 1.40nMAssay Description:Inhibition of FTase (unknown origin) assessed as transfer of [H3]farnesyl from [H3]farnesyl pyrophosphate to trichloroacetic acid-precipitable HaRas-...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/2/2020
Entry Details Article
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TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL

LigandBDBM50495901(CHEMBL3115253)Copy SMILESCopy InChI

Affinity DataIC50: 300nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/2/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL