BDBM50499105 CHEMBL3735401

SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnn(CC(=O)N(C)C)c1

InChI Key InChIKey=IDGNCVHQDDOPND-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50499105   

TargetALK tyrosine kinase receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50499105(CHEMBL3735401)
Affinity DataIC50: 17nMAssay Description:Inhibition of gatekeeper ALK L1196M mutant (unknown origin) using poly (Glu, Tyr)4:1 substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50499105(CHEMBL3735401)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu, Tyr)4:1 substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50499105(CHEMBL3735401)
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type EML4-ALK (unknown origin) expressed in mouse Ba/F3 cells assessed as cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50499105(CHEMBL3735401)
Affinity DataIC50: 3nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50499105(CHEMBL3735401)
Affinity DataIC50: 13nMAssay Description:Inhibition of Ret V804L (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50499105(CHEMBL3735401)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CSNK2A1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50499105(CHEMBL3735401)
Affinity DataIC50: 465nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50499105(CHEMBL3735401)
Affinity DataIC50: 12nMAssay Description:Inhibition of Ret V804M (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK4(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50499105(CHEMBL3735401)
Affinity DataIC50: 14nMAssay Description:Inhibition of CLK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50499105(CHEMBL3735401)
Affinity DataIC50: 14nMAssay Description:Inhibition of IRAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50499105(CHEMBL3735401)
Affinity DataIC50: 2nMAssay Description:Inhibition of ALK G1202R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50499105(CHEMBL3735401)
Affinity DataIC50: 2nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50499105(CHEMBL3735401)
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50499105(CHEMBL3735401)
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50499105(CHEMBL3735401)
Affinity DataIC50: 12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50499105(CHEMBL3735401)
Affinity DataIC50: 13nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed