BDBM50499585 CHEMBL3740850

SMILES COCCOc1cc2c(Nc3cccc(c3)C#C)ncnc2cc1OCCOC(=O)C(C)c1ccc2cc(OC)ccc2c1

InChI Key InChIKey=JBAKNRRHHNECIM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50499585   

TargetEpidermal growth factor receptor(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50499585(CHEMBL3740850)
Affinity DataIC50: 72nMAssay Description:Inhibition of EGFR (unknown origin) using tyrosine 4 as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50499585(CHEMBL3740850)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50499585(CHEMBL3740850)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of COX-2 in human HCC827 cells assessed as decrease in PGE2 level by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50499585(CHEMBL3740850)
Affinity DataIC50: 2.45E+4nMAssay Description:Inhibition of Ovine COX-1 preincubated for 15 mins by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed