BDBM50500357 CHEMBL3746522::US11066363, Compound 31

SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnn(CCN(C)C)c1

InChI Key InChIKey=XHGQFRKDGWOOTC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50500357   

LigandPNGBDBM50500357(CHEMBL3746522 | US11066363, Compound 31)
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type EML4-ALK (unknown origin) expressed in mouse Ba/F3 cells assessed as cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSRSF protein kinase 1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50500357(CHEMBL3746522 | US11066363, Compound 31)
Affinity DataIC50: 1.91nMAssay Description:SRPK1 Inhibitory Activities of the Compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent

TargetSRSF protein kinase 2(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50500357(CHEMBL3746522 | US11066363, Compound 31)
Affinity DataIC50: 6.60nMAssay Description:SRPK1 Inhibitory Activities of the Compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
Go to US Patent