BDBM50500360 CHEMBL3747134::US11066363, Compound 9

SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cc[nH]n1

InChI Key InChIKey=JINIKYUAUCGQAS-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50500360   

TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL

LigandBDBM50500360(CHEMBL3747134 | US11066363, Compound 9)Copy SMILESCopy InChI

Affinity DataIC50: 50nMAssay Description:Inhibition of wild type EML4-ALK (unknown origin) expressed in mouse Ba/F3 cells assessed as cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/4/2020
Entry Details Article
Copy Entry DOIPubMed
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TargetSRSF protein kinase 1(Human)
Dana-Farber Cancer Institute

US Patent

LigandBDBM50500360(CHEMBL3747134 | US11066363, Compound 9)Copy SMILESCopy InChI

Affinity DataIC50: 1.15nMAssay Description:SRPK1 Inhibitory Activities of the Compounds.More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/19/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL