BDBM50500914 CHEMBL3799831

SMILES CN(C)C(=O)c1cc(CN2CCOc3c(F)cccc23)c2oc(cc(=O)c2c1)N1CCOCC1

InChI Key InChIKey=ZCBWPTBPKMKOLE-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50500914   

LigandPNGBDBM50500914(CHEMBL3799831)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant PI3Kdelta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500914(CHEMBL3799831)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50500914(CHEMBL3799831)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500914(CHEMBL3799831)
Affinity DataIC50: 15nMAssay Description:Tight binding affinity to human recombinant PI3Kdelta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50500914(CHEMBL3799831)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500914(CHEMBL3799831)
Affinity DataIC50: 12nMAssay Description:Inhibition of PI3Kbeta in PTEN deficient human MDA-MB-468 cells assessed as inhibition of AKT phosphorylation at Ser-473 residue after 2 hrs by plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50500914(CHEMBL3799831)
Affinity DataIC50: 690nMAssay Description:Inhibition of DNAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500914(CHEMBL3799831)
Affinity DataIC50: 9.40E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500914(CHEMBL3799831)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant PI3Kalpha using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50500914(CHEMBL3799831)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500914(CHEMBL3799831)
Affinity DataIC50: 47nMAssay Description:Inhibition of PI3Kdelta in human JeKo1 cells assessed as inhibition of AKT phosphorylation at Ser-473 residue after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50500914(CHEMBL3799831)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500914(CHEMBL3799831)
Affinity DataIC50: 10nMAssay Description:Tight binding affinity to human recombinant PI3Kalpha using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50500914(CHEMBL3799831)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500914(CHEMBL3799831)
Affinity DataIC50: 10nMAssay Description:Tight binding affinity to human recombinant PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50500914(CHEMBL3799831)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500914(CHEMBL3799831)
Affinity DataIC50: 570nMAssay Description:Inhibition of human recombinant PI3Kgamma using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins by l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed