BDBM50501437 CHEMBL4101347

SMILES O=c1n(Cc2cccc3cccnc23)cnc2sc3CC(CCc3c12)NCc1ccc(cc1)C#N

InChI Key InChIKey=QRGAZSXFYMPBRM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50501437   

TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501437(CHEMBL4101347)
Affinity DataIC50: 390nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50501437(CHEMBL4101347)
Affinity DataIC50: 4.21E+4nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SIRT1 (1 to 747 end residues) expressed in Escherichia coli using p53 derived (379 to 382 resid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM50501437(CHEMBL4101347)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged SIRT3 (101 to 399 residues) expressed in Escherichia coli using p53 derived (379 to 382 residue...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed