BDBM50501649 CHEMBL4083341

SMILES C(c1nnc2sc(nn12)-c1ccc2OCOc2c1)n1nnc2ccccc12

InChI Key InChIKey=OMJCQXZLUQBYND-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50501649   

TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501649(CHEMBL4083341)
Affinity DataIC50: 3.96E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) at preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501649(CHEMBL4083341)
Affinity DataIC50: 6.75E+3nMAssay Description:Inhibition of DOT1L in human MV4-11 cells assessed as reduction in cell viability after 72 hrs by alamar blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed