BDBM50501855 CHEMBL4474593

SMILES NC(=O)c1cccc2C(=O)\C(Oc12)=C\c1ccc(cc1)C(=O)N1CCN(CC1)c1nc2ccccc2[nH]1

InChI Key InChIKey=UVYVRAATXCFMQQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50501855   

TargetPoly [ADP-ribose] polymerase 2(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50501855(CHEMBL4474593)
Affinity DataIC50: 4nMAssay Description:Inhibition of human N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 insect cells using histone as substrate mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50501855(CHEMBL4474593)
Affinity DataIC50: 4nMAssay Description:Inhibition of human N-terminal GST-tagged PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 insect cells using histone as substrate mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50501855(CHEMBL4474593)
Affinity DataIC50: 17nMAssay Description:Inhibition of human full-length N-terminal GST-tagged PARP1 expressed in baculovirus infected Sf9 insect cells using histone as substrate measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50501855(CHEMBL4474593)
Affinity DataIC50: 18nMAssay Description:Inhibition of human full-length N-terminal GST-tagged PARP1 expressed in baculovirus infected Sf9 insect cells using histone as substrate measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50501855(CHEMBL4474593)
Affinity DataIC50: 131nMAssay Description:Inhibition of human N-terminal GST-tagged TNKS1 (1001 to 1327 residues) expressed in baculovirus infected Sf9 insect cells using histone as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50501855(CHEMBL4474593)
Affinity DataIC50: 198nMAssay Description:Inhibition of human N-terminal GST-tagged TNKS2 (667 to 1166 residues) expressed in baculovirus infected Sf9 insect cells using histone as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed