BDBM50503853 CHEMBL4545565
SMILES Cc1c2CCNC(=O)c2ccc1-c1ccnc(c1)C(F)(F)F
InChI Key InChIKey=ORKVHLCVQDSOAL-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 21 hits for monomerid = 50503853
TargetProtein mono-ADP-ribosyltransferase PARP15(Human)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 6.31E+4nMAssay Description:Inhibition of human PARP15 catalytic domain assessed as reduction in MARylation of SRPK2 substrate after 60 mins in presence of 6-a-NAD+ by chemifluo...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP15(Human)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 6.30E+4nMAssay Description:Inhibition of human PARP15 catalytic domain assessed as reduction in MARylation of SRPK2 substrate after 60 mins in presence of 6-a-NAD+ by chemifluo...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human PARP10 catalytic domain assessed as reduction in MARylation of His6-tagged SRPK2 substrate after 60 mins in presence of NAD+ by c...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full length human PARP2 assessed as reduction in MARylation of SRPK2 substrate after 60 mins in presence of 6-a-NAD+ by chemifluorescen...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 1.91E+4nMAssay Description:Inhibition of human PARP7 assessed as reduction in MARylation of SRPK2 substrate after 60 mins in presence of 6-a-NAD+ by chemifluorescence assayMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP16(Human)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 6.76E+3nMAssay Description:Inhibition of human transmembrane domain deficient His-SUMO-tagged PARP16 expressed in Escherichia coli BL21 assessed as reduction in MARylation of H...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataEC50: 2.30E+3nMAssay Description:Inhibition of GFP-tagged human PARP10 expressed in HEK293T cells assessed as reduction in high molecular weight target protein MARylation after 3 hrs...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 6.10E+4nMAssay Description:Inhibition of human PARP14 catalytic-WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21 assessed as reduction in MARylation of SRP...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of human PARP7 assessed as reduction in MARylation of SRPK2 substrate after 60 mins in presence of 6-a-NAD+ by chemifluorescence assayMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 1.82E+3nMAssay Description:Inhibition of human PARP10 catalytic domain assessed as reduction in MARylation of His6-tagged SRPK2 substrate after 60 mins in presence of NAD+ by c...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataEC50: 1.10E+4nMAssay Description:Inhibition of GFP-tagged human PARP10 expressed in HEK293T cells assessed as reduction in auto-MARylation after 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP16(Human)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of human transmembrane domain deficient His-SUMO-tagged PARP16 expressed in Escherichia coli BL21 assessed as reduction in MARylation of H...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 6.03E+4nMAssay Description:Inhibition of human PARP14 catalytic-WWE domain (1459 to 1801 residues) expressed in Escherichia coli BL21 assessed as reduction in MARylation of SRP...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP12(Human)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of GFP-tagged human PARP12 expressed in HEK293T cells assessed as reduction in auto-MARylation after 60 mins in presence of 6-a-NAD+ by ch...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP8(Human)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of GFP-tagged human PARP8 expressed in HEK293T cells assessed as reduction in auto-MARylation after 60 mins in presence of 6-a-NAD+ by che...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human PARP5B catalytic domain (1 to 572 residues) assessed as reduction in MARylation of SRPK2 substrate after 60 mins in presence of 6...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full length human PARP3 assessed as reduction in MARylation of SRPK2 substrate after 60 mins in presence of 6-a-NAD+ by chemifluorescen...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full length human PARP1 assessed as reduction in MARylation of SRPK2 substrate after 60 mins in presence of 6-a-NAD+ by chemifluorescen...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP11(Human)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 5.13E+4nMAssay Description:Inhibition of full length human His-SUMO-tagged PARP11 expressed in Escherichia coli BL21 assessed as reduction in MARylation of His6-tagged SRPK2 su...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP11(Human)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 5.17E+4nMAssay Description:Inhibition of full length human His-SUMO-tagged PARP11 expressed in Escherichia coli BL21 assessed as reduction in MARylation of His6-tagged SRPK2 su...More data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP4(Human)
Oregon Health and Science University
Curated by ChEMBL
Oregon Health and Science University
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human PARP4 BRCT-catalytic domain (1 to 572 residues) assessed as reduction in MARylation of SRPK2 substrate after 60 mins in presence ...More data for this Ligand-Target Pair