BDBM50505169 CHEMBL4543919

SMILES OC(c1ccc(cc1)C#N)c1cc(O)c2C(=O)c3ccccc3C(=O)c2c1O

InChI Key InChIKey=CMACGNWYZVINDH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50505169   

TargetDNA topoisomerase 2-alpha/2-beta(Human)
Guangxi University

Curated by ChEMBL
LigandPNGBDBM50505169(CHEMBL4543919)
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of topoisomerase 2 in human CNE1 cells assessed as reduction in cell growth measured after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Guangxi University

Curated by ChEMBL
LigandPNGBDBM50505169(CHEMBL4543919)
Affinity DataIC50: 1.28E+4nMAssay Description:Inhibition of topoisomerase 2 in human HepG2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Guangxi University

Curated by ChEMBL
LigandPNGBDBM50505169(CHEMBL4543919)
Affinity DataIC50: 1.49E+4nMAssay Description:Inhibition of topoisomerase 2 in human HeLa cells assessed as reduction in cell growth measured after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Guangxi University

Curated by ChEMBL
LigandPNGBDBM50505169(CHEMBL4543919)
Affinity DataIC50: 1.76E+4nMAssay Description:Inhibition of topoisomerase 2 in human A549 cells assessed as reduction in cell growth measured after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Guangxi University

Curated by ChEMBL
LigandPNGBDBM50505169(CHEMBL4543919)
Affinity DataIC50: 2.69E+4nMAssay Description:Inhibition of topoisomerase 2 in human MDA-MB-231 cells assessed as reduction in cell growth measured after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Guangxi University

Curated by ChEMBL
LigandPNGBDBM50505169(CHEMBL4543919)
Affinity DataIC50: 2.86E+4nMAssay Description:Inhibition of topoisomerase 2 in human MCF7 cells assessed as reduction in cell growth measured after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed