BDBM50505743 CHEMBL4582624

SMILES Cn1cc(cn1)Nc2nc3ccc(nc3c(n2)NC4CCC(CC4)N5CCN(CC5)C(=O)OC)CC#N

InChI Key InChIKey=RPGMSHCJIWHISY-UHFFFAOYSA-N

Data  12 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50505743   

TargetCyclin-C(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505743(CHEMBL4582624)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CDK8/cyclinC expressed in Baculovirus systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505743(CHEMBL4582624)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human recombinant CLK1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505743(CHEMBL4582624)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505743(CHEMBL4582624)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human recombinant CLK2 expressed in Baculovirus systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505743(CHEMBL4582624)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505743(CHEMBL4582624)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant CLK4 expressed in Baculovirus systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505743(CHEMBL4582624)
Affinity DataIC50: 27nMAssay Description:Inhibition of IRAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505743(CHEMBL4582624)
Affinity DataIC50: 46nMAssay Description:Inhibition of IRAK4 (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505743(CHEMBL4582624)
Affinity DataIC50: 4nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of 5 mM ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505743(CHEMBL4582624)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CLK3 expressed in Baculovirus systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505743(CHEMBL4582624)
Affinity DataIC50: 3nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50505743(CHEMBL4582624)
Affinity DataIC50: 170nMAssay Description:Inhibition of IRAK4 (unknown origin) phosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)