BDBM50506052 CHEMBL4446191

SMILES CC(C)Cc1nc(-c2ccc(Cl)o2)n(c1C)-c1c(Cl)ccc(N2CC(C2)C(O)=O)c1Cl

InChI Key InChIKey=RNPZPMWEPYZAJN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50506052   

TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506052(CHEMBL4446191)
Affinity DataIC50: 4nMAssay Description:Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Global Discovery Chemistry

Curated by ChEMBL
LigandPNGBDBM50506052(CHEMBL4446191)
Affinity DataIC50: 32nMAssay Description:Inhibition of human full-length eGFP-tagged RORgammat expressed in human HUT78 T-cells assessed as inhibition of PMA/CD3 monoclonal antibody stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed