BDBM50507319 CHEMBL4439338

SMILES COc1cc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1OCCCN1CCNCCNCC1

InChI Key InChIKey=JBSDBYXRHGAOIT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50507319   

TargetEpidermal growth factor receptor(Human)
Beijing University of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50507319(CHEMBL4439338)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of wild type human N-terminal GST-tagged EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Beijing University of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50507319(CHEMBL4439338)
Affinity DataIC50: 9.60nMAssay Description:Inhibition of wild type human N-terminal His-tagged HER2 cytoplasmic domain (676 to 1255 residues) expressed in baculovirus expression system after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Beijing University of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50507319(CHEMBL4439338)
Affinity DataIC50: 41nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR cytoplasmic domain (669 to 1210 residues) T790M mutant expressed in baculovirus expression system afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed