BDBM50507702 CHEMBL4565933::US11535598, Compound 8

SMILES ONC(=O)c1ccc(Cn2c3cc(Cl)ccc3c(=O)n(CCc3ccccc3)c2=O)cc1

InChI Key InChIKey=BQXYNQBAMODFJS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50507702   

TargetHistone deacetylase 6(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM50507702(CHEMBL4565933 | US11535598, Compound 8)
Affinity DataIC50: 21nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM50507702(CHEMBL4565933 | US11535598, Compound 8)
Affinity DataIC50: 22nMAssay Description:Inhibition of human full-length recombinant HDAC6 expressed in baculovirus infected Sf9 insect cells using fluorogenic peptide RHKKAc as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507702(CHEMBL4565933 | US11535598, Compound 8)
Affinity DataIC50: 1.64E+3nMAssay Description:Inhibition of human full-length recombinant HDAC8 expressed in baculovirus infected Sf9 insect cells using fluorogenic peptide RHKAcKAc as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507702(CHEMBL4565933 | US11535598, Compound 8)
Affinity DataIC50: 1.64E+3nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507702(CHEMBL4565933 | US11535598, Compound 8)
Affinity DataIC50: 9.54E+3nMAssay Description:Inhibition of human full-length recombinant HDAC1 expressed in baculovirus infected Sf9 insect cells using fluorogenic peptide RHKKAc as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507702(CHEMBL4565933 | US11535598, Compound 8)
Affinity DataIC50: 9.54E+3nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent