BDBM50508014 CHEMBL4450479

SMILES COc1ccc2c(ccnc2c1)C1CCN(CC1)C(=O)c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=VBSDNKDEIMVTQP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50508014   

TargetMitogen-activated protein kinase 7(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50508014(CHEMBL4450479)
Affinity DataIC50: 110nMAssay Description:Inhibition of His-tagged MAP2K5 activated N-terminal GST-tagged recombinant human ERK5 (1 to 398 residues) expressed in Escherichia coli using biotin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50508014(CHEMBL4450479)
Affinity DataIC50: 710nMAssay Description:Inhibition of ERK5 in human SN12C cells transduced with MEF2-responsive transcription element assessed as reduction in MEF2 transcription by measurin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed