BDBM50508414 CHEMBL4456850

SMILES Cn1ccc(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(CC2)C(F)F)n1

InChI Key InChIKey=YPJSTCOAXTXCOC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50508414   

TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50508414(CHEMBL4456850)
Affinity DataIC50: 320nMAssay Description:Inhibition of recombinant full-length human C-terminal His6-tagged PARG (1 to 976 residues) expressed in Escherichia coli BL21 (DE3) cells using 6HIS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50508414(CHEMBL4456850)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed