BDBM50508418 CHEMBL4555002

SMILES CCn1c2ccc(cc2c(=O)n(Cc2cc(C)on2)c1=O)S(=O)(=O)NC1(CF)CC1

InChI Key InChIKey=KFMMUYOIQZVTHD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50508418   

TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50508418(CHEMBL4555002)
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of recombinant full-length human C-terminal His6-tagged PARG (1 to 976 residues) expressed in Escherichia coli BL21 (DE3) cells using 6HIS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50508418(CHEMBL4555002)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed