BDBM50508756 CHEMBL4549553::US11312713, Example 1

SMILES CCc1nc2cnc3ccc(Cl)cc3c2n1[C@@H]1CCO[C@H](CC#N)C1

InChI Key InChIKey=JJHOHPOGCOEIHB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50508756   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Drexel University

Curated by ChEMBL
LigandPNGBDBM50508756(CHEMBL4549553 | US11312713, Example 1)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of GST-tagged LRRK2 G2019S mutant (unknown origin) expressed in baculovirus expression system using fluorescein-labeled LRRKtide as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50508756(CHEMBL4549553 | US11312713, Example 1)
Affinity DataIC50: 8.87nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Drexel University

Curated by ChEMBL
LigandPNGBDBM50508756(CHEMBL4549553 | US11312713, Example 1)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant wild-type GST-tagged LRRK2 (unknown origin) expressed in baculovirus expression system using fluorescein-labeled LRRKtide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Drexel University

Curated by ChEMBL
LigandPNGBDBM50508756(CHEMBL4549553 | US11312713, Example 1)
Affinity DataIC50: 10.2nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent