BDBM50509343 CHEMBL4472668

SMILES CN1CCC(CC1)Oc1ccc2c3CCN(Cc3c(=O)oc2c1)C(=O)c1ccc(cc1)C(O)=O

InChI Key InChIKey=RKXKRGYQCAZNES-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50509343   

LigandPNGBDBM50509343(CHEMBL4472668)
Affinity DataIC50: 390nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50509343(CHEMBL4472668)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed