BDBM50509619 CHEMBL4440988

SMILES NC(=O)c1cnc2ccc(nn12)-c1c(ncn1CC(F)F)-c1ccc(F)cc1

InChI Key InChIKey=NFBPYNYPYRTHSU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50509619   

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50509619(CHEMBL4440988)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of His-tagged TGFBR1 kinase domain T204D mutant (unknown origin) incubated for 1 hr by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-2(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50509619(CHEMBL4440988)
Affinity DataIC50: 2.93E+3nMAssay Description:Inhibition of wild type His-tagged TGFBR2 kinase domain (unknown origin) incubated for 1 hr by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50509619(CHEMBL4440988)
Affinity DataIC50: 660nMAssay Description:Inhibition of TGFbetaR1 in TGFbeta-stimulated mink Mv1Lu cells assessed as reduction in SMAD nuclear translocation preincubated for 1 hr followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50509619(CHEMBL4440988)
Affinity DataIC50: 420nMAssay Description:Inhibition of TGFBR1 in TGFbeta-stimulated human NHLF cells assessed as reduction in SMAD2 nuclear translocationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed