BDBM50510249 CHEMBL4463318

SMILES COc1ccc(cc1)-c1ccc2ncc(-c3nnco3)c(NCCCN3CCOCC3)c2c1

InChI Key InChIKey=HOHLTWPTYNTYRD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50510249   

TargetDNA topoisomerase 1(Human)
Csir-Indian Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50510249(CHEMBL4463318)
Affinity DataIC50: 1.79E+3nMAssay Description:Inhibition of recombinant human Top1 derived from human MCF7 cell extract incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetDNA topoisomerase 1(Human)
Csir-Indian Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50510249(CHEMBL4463318)
Affinity DataIC50: 1.79E+3nMAssay Description:Poison activity at recombinant human TOP1 expressed in baculovirus infected Sf9 insect cells assessed as decrease in relaxed supercoiled pBS(SK+) DNA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Csir-Indian Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50510249(CHEMBL4463318)
Affinity DataIC50: 2.51E+3nMAssay Description:Poison activity at TOP1 in human MCF7 cells assessed as decrease in relaxed supercoiled pBS(SK+) DNA mobility measured after 30 mins by ethidium brom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed