BDBM50510302 CHEMBL4452772

SMILES CC(Oc1cc(cnc1N)-c1cccc(c1)N1CCNCC1)c1cc(F)ccc1Cl

InChI Key InChIKey=FGLXXDYNGCFGIO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50510302   

TargetTyrosine-protein kinase JAK2(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50510302(CHEMBL4452772)
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant N-terminal hexahistidine tagged JAK2 JH1 catalytic domain (835 to 1132 residues) expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50510302(CHEMBL4452772)
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant N-terminal hexahistidine tagged JAK1 JH1 catalytic domain (854 to 1154 residues) expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50510302(CHEMBL4452772)
Affinity DataIC50: 2.53E+3nMAssay Description:Inhibition of TYK2 (unknown origin) using peptide as substrate preincubated for 10 mins followed by substrate addition by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50510302(CHEMBL4452772)
Affinity DataIC50: 2.79E+3nMAssay Description:Inhibition of human recombinant C-terminal hexahistidine tagged JAK3 JH1 catalytic domain (811 to 1124 residues) expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed