BDBM50510770 CHEMBL4591139

SMILES [H][C@]12CSC(N)=N[C@]1(CO[C@@H]2C(C)(F)F)c1cc(NC(=O)c2ccc(cn2)C(F)(F)F)ccc1F

InChI Key InChIKey=XRFGNLFEFGYHSU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50510770   

TargetBeta-secretase 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50510770(CHEMBL4591139)
Affinity DataIC50: 1nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells transfected with APP695 assessed as reduction in amyloidbeta (1 to 40 residues) incubated for 24 hrs by sa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50510770(CHEMBL4591139)
Affinity DataIC50: 12nMAssay Description:Inhibition of human BACE1 expressed in HEK293 cells incubated for 16 to 24 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50510770(CHEMBL4591139)
Affinity DataIC50: 602nMAssay Description:Inhibition of human BACE2 expressed in HEK293 cells incubated for 16 to 24 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed