BDBM50510872 CHEMBL4303404

SMILES Cc1noc2[C@H](CC(N)=O)N=C(c3ccc(Cl)cc3)c3ccccc3-c12

InChI Key InChIKey=GCWIQUVXWZWCLE-UHFFFAOYSA-N

Data  21 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50510872   

TargetATPase family AAA domain-containing protein 2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 8.00E+4nMAssay Description:Displacement of biotinylated JQ1 from ATAD2 bromodomain (unknown origin) incubated for 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBromodomain-containing protein 8(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 1.50E+4nMAssay Description:Binding affinity to BRD8 bromodomain (unknown origin) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 2.00E+4nMAssay Description:Binding affinity to TRIM24 bromodomain (unknown origin) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetATPase family AAA domain-containing protein 2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 8.00E+4nMAssay Description:Binding affinity to ATAD2 bromodomain (unknown origin) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTranscription activator BRG1(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 2.00E+4nMAssay Description:Binding affinity to BRG1 bromodomain (unknown origin) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated JQ1 from CBP bromodomain (unknown origin) incubated for 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 39nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) using biotinylated ligand incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataEC50:  180nMAssay Description:Inhibition of BRD4 BD1 in human MV4-11 cells assessed as reduction of MYC RNA expression after 4 hrs by PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPeregrin(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated JQ1 from BRPF1 bromodomain (unknown origin) incubated for 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated JQ1 from PCAF bromodomain (unknown origin) incubated for 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTranscription activator BRG1(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated JQ1 from BRG1 bromodomain (unknown origin) incubated for 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 39nMAssay Description:Inhibition of BRD4 bromodomain-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated JQ1 from TRIM24 bromodomain (unknown origin) incubated for 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBromodomain-containing protein 8(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 1.50E+4nMAssay Description:Displacement of biotinylated JQ1 from BRD8 bromodomain (unknown origin) incubated for 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 2.00E+4nMAssay Description:Binding affinity to CBP bromodomain (unknown origin) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBromodomain-containing protein 9(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 8.00E+4nMAssay Description:Binding affinity to BRD9 bromodomain (unknown origin) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPeregrin(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 2.00E+4nMAssay Description:Binding affinity to BRPF1 bromodomain (unknown origin) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 2.00E+4nMAssay Description:Binding affinity to PCAF bromodomain (unknown origin) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBromodomain-containing protein 9(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 8.00E+4nMAssay Description:Displacement of biotinylated JQ1 from BRD9 bromodomain (unknown origin) incubated for 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 39nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 3nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50: 11nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed