BDBM50511545 CHEMBL4581567

SMILES CN1CCCc2c1nc([nH]c2=O)N1CCC2(CC1)C(=O)N(CC1COC1)c1cc(F)cc(F)c21

InChI Key InChIKey=BGISDNKMCUOWSJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50511545   

TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
Japanese Foundation For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50511545(CHEMBL4581567)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Japanese Foundation For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50511545(CHEMBL4581567)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Japanese Foundation For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50511545(CHEMBL4581567)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 ARC5-SAM-PARP domain (613 to 1166 residues) expressed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
Japanese Foundation For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50511545(CHEMBL4581567)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed