BDBM50512025 CHEMBL4451916

SMILES NS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(cc1)C(F)(F)F)C(=O)OCCCN1CCOCC1

InChI Key InChIKey=ZHWIKUYCPQHTGA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50512025   

TargetProstaglandin G/H synthase 2(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50512025(CHEMBL4451916)
Affinity DataIC50: 210nMAssay Description:Inhibition of COX2 (unknown origin) using arachidonic acid as substrate incubated for 10 mins by Ellman's reagent based COX-1/COX-2 ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50512025(CHEMBL4451916)
Affinity DataIC50: 750nMAssay Description:Inhibition of Sprague-Dawley rat 5-LOX assessed as calcium ionophore A23187-stimulated LTB4 production preincubated for 30 mins followed by calcium i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50512025(CHEMBL4451916)
Affinity DataIC50: 2.85E+4nMAssay Description:Inhibition of COX1 (unknown origin) using arachidonic acid as substrate incubated for 10 mins by Ellman's reagent based COX-1/COX-2 ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed