BDBM50512474 CHEMBL4566514

SMILES Cn1ccc(n1)-c1n[nH]c2ccc(NCc3cc(F)ccc3S(C)(=O)=O)cc12

InChI Key InChIKey=YTFMVOGDUWRAJU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50512474   

TargetHigh affinity nerve growth factor receptor(Human)
Asahi Kasei Pharma

Curated by ChEMBL
LigandPNGBDBM50512474(CHEMBL4566514)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human GST-tagged TRKA (436 to 790) expressed in baculovirus expression system using TK-biotin peptide as substrate incubated for 45 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Asahi Kasei Pharma

Curated by ChEMBL
LigandPNGBDBM50512474(CHEMBL4566514)
Affinity DataIC50: 105nMAssay Description:Antagonist activity at prolink-tagged full length human TrkA expressed in U2OS cells assessed as inhibition of NGF-induced receptor phosphorylation b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed