BDBM50512917 CHEMBL4527700

SMILES [H][C@@]12C[C@]1([H])C[C@H]([C@@H](C2)C(=O)Nc1cnn(C)c1C(F)(F)F)C(=O)c1ccc(cc1)-c1cc[nH]n1

InChI Key InChIKey=CECZJTAXCQODAY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50512917   

LigandPNGBDBM50512917(CHEMBL4527700)
Affinity DataIC50: 13nMAssay Description:Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50512917(CHEMBL4527700)
Affinity DataIC50: 50nMAssay Description:Inhibition of FLAP in human whole blood assessed as reduction in calcium ionophore-stimulated LTB4 production preincubated for 30 mins followed by ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50512917(CHEMBL4527700)
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of recombinant human CYP2C9 expressed in Escherichia coli assessed as maximum reduction in metabolite formation using coumarin based subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed